Abstracts

The Role of Probiotic Lactic Acid Bacteria and Bifidobacteria in the Prevention and Treatment of Inflammatory Bowel Disease and Other Related Diseases: A Systematic Review of Randomized Human Clinical Trials

Inflammatory bowel disease (IBD), which includes Crohn’s disease (CD) and ulcerative colitis (UC), is a chronic inflammation of the small intestine and colon caused by a dysregulated immune response to host intestinal microbiota in genetically susceptible subjects. A number of fermented dairy products contain lactic acid bacteria (LAB) and bifidobacteria, some of which have been characterised as probiotics that can modify the gut microbiota and may be beneficial for the treatment and the prevention of IBD.

The objective of this review was to carry out a systematic search of LAB and bifidobacteria probiotics and IBD, using the PubMed and Scopus databases, defined by a specific equation using MeSH terms and limited to human clinical trials. The use of probiotics and/or synbiotics has positive effects in the treatment and maintenance of UC, whereas in CD clear effectiveness has only been shown for synbiotics.

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You, Jet Lag, Microbiota and Fat Deposition

If you have ever travelled across time zones you will be familiar with the adverse effects on your physical function an loss of clarity and productivity – well it seems that the organisms present in your gut, share the same trip and to some extent the same consequences. Published in Cell researchers explored the consequences of this effect on adiposity and metabolic functionality. Whilst they are naturally cautious about translation from a mouse model to a human one, they noted some interesting observations, that may explain some peoples adverse physical consequences derived in part as a result of cross time zone travel.[1]

Organisms ranging from bacteria to humans have circadian clocks to help them synchronise their biological activities to the time of day. This paper now reveals that gut microbes in mice and humans have circadian rhythms that are controlled by the biological clock of the host in which they reside. Disruption of the circadian clock in the host alters the rhythms and composition of the microbial community, potentially leading to obesity and metabolic problems.

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Reversal of cognitive decline: A novel therapeutic program

The problem facing may people in the coming decades is that of loss of cognition, and for those already facing this reality it may be of some comfort to know that a lifestyle approach has generated very positive recovery of function using a simple set of interventions. Published in the journal Aging This report describes a novel, comprehensive, and personalised therapeutic program that is based on the underlying pathogenesis of Alzheimer’s disease, and which involves multiple modalities designed to achieve metabolic enhancement for neurodegeneration (MEND).[1]

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Apples, Inducers of Eubiosis Driven Weight Management

Apples; great for SCFA production, restoring bacterial eubiosis in a disrupted gut and likely able to assist with weight management, say scientists in the journal Food Chemistry.[1] Apples, in general, have shown to protect against human chronic diseases due to their content of fibre and phenolic compounds. These bioactive compounds have low availability and can potentially reach to colon, modulate the balance of bacterial populations in the gut, and influence the host physiology. The apple health benefits are, in part, due to the interaction of fibre and phenolics with gut microbiota that results in changes in phenolic bioavailability and activity, and the production of short chain fatty acids (SCFAs) after fibre fermentation.

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Ginger Vs Migraines Compared to Medication

The journal Phytotherapy Research published an interesting article exploring the use of ginger as a treatment for migraine and comparing it to the commonly prescribed medication sumatriptan – the results are encouraging for those seeking non drug based interventions.

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Efficacy of Vitamin C as an Adjunct to Fluoxetine Therapy in Paediatric Major Depressive Disorder

A paper out in the Journal of Nutrition raises an interesting notion that augmentation of Fluoextine in paediatric patients may well enhance the clinical outcomes. Putting aside for one moment the increasing challenges faced by anti-depressants to be validated as a worthwhile therapy in mild to moderate depression, plus their numerous side effect it raises an interesting possibility.[1] A safe oral supplement of ascorbates may either biochemically or circumstantially enhance recovery in young patients and that is something worth considering.[2]

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Efficacy and Safety of Saccharomyces Boulardii for Acute Diarrhea.

Saccharomyces is a non-colonising yeast used for the last 70 plus years as a therapeutic agent for the relief and management of gastrointestinal distress. Whilst its community use as a by-product of lychee fermentation was well understood in indo china and other nations, in particular for the relief of choleric dysentery it was after Henri Boulard set up the French pharmaceutical company to exploit its potential that studies began. So the recent publication (July 2014) of a review paper in the well known journal Pediatrics is a helpful means of qualifying its use in the paediatric population[1]

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Fish Oil Supplements Reduce Incidence of Cognitive Decline, Brain Atrophy

Regular use of fish oil supplements (FOS) was associated with a significant reduction in cognitive decline and brain atrophy in older adults, according to a study published early online ahead of the print edition of the journal Alzheimer’s & Dementia.[1]

The study examined the relationship between FOS use and indicators of cognitive decline during the Alzheimer’s Disease Neuroimaging Initiative (ADNI)

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Perilla Extract (Benegut®) Improves IBS symptoms

A study published in the BMC Complementary and Alternative Medicine Journal identifies a number of benefits and improved function, achieved in people with IBS ( a functional loss of tolerance in the GI Tract) when consuming a 300mg daily dose of Perilla Extract.[1]

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What You Eat May Affect Your Body’s Internal Biological Clock

Source : Cell Press

Food not only nourishes the body but also affects its internal biological clock, which regulates the daily rhythm of many aspects of human behaviour and biology. Researchers reporting in the Cell Press journal Cell Reports provide new insights into how adjusting the clock through dietary manipulation may help patients with various conditions and show that insulin may be involved in resetting the clock.[1]

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