Faecal Transplantation Works for C. difficile Colitis

I have written a number of times about the role of faecal transplantation in the established intervention for Clostridium difficile and have hinted at the possible cross mechanism benefits of inducing commensal bacteria that favour tolerance into the gastrointestinal tract. The implication being, that individuals experiencing illness driven by loss of immunological tolerance, not simply within the digestive tract, but systemically may benefit from an evolutionary transplant.

Whilst there are practical considerations – there has been one small study on home administration[1] and numerous anecdotal discussions regarding its use in a wide range of illnesses, for which a recovery has been confirmed.

A recent study ( March 2012)  published in the journal Gastroenterology is one of the largest exploring Clostridium difficile patients and their outcomes following faecal transplantation.[2]

Patients who suffer from protracted Clostridium difficile colitis despite receiving oral antibiotic therapy, often for months, have become a challenge for physicians all over the world.

The investigators reviewed data from 70 adults (mean age, 73; 86% outpatients) who had received up to 12 courses of antibiotics for CDI; most had received 3 to 6 courses. Most stool donors were close relatives of the patient. Transplantations were performed using a uniform protocol, which involved bowel preparation with an oral polyethylene glycol solution, followed by an infusion of stool into the caecum via colonoscope.

Three months after transplantation, 66 of the 70 patients reported complete resolution of symptoms. The four who did not respond all had the virulent 027 strain of C. difficile as well as other serious medical illnesses; all died within 3 months of transplantation. In the year following transplantation, four additional patients relapsed; two were treated successfully with antibiotics, and two received another faecal transplant. No complications of transplantation were reported.

No other C. difficile treatment achieves anything like the 94% eradication rate reported in this study, even in patients with relatively mild disease. Faecal transplantation would probably become the gold-standard treatment for CDI if the logistics of arranging it were not so daunting.

However, the discomfiture displayed by the physician is less of a problem for the ill patient – once the concept is fully understood and the application standardised – in as much as there is a preferred in hospital or at home methodology and pre transplant prep, then this therapy will be used more and more saving lives, money and families from unwanted misery and even death. Physician driven exclusion based on the ‘yuck’ factor is a poor and emotive based reason to avoid a compellingly safe and effective treatment.

References


[1] Silverman MS, Davis I, Pillai DR. Success of self-administered home fecal transplantation for chronic Clostridium difficile infection. Clin Gastroenterol Hepatol. 2010 May;8(5):471-3. Epub 2010 Feb 1. View Abstract

[2] Mattila E, Uusitalo-Seppälä R, Wuorela M, Lehtola L, Nurmi H, Ristikankare M, Moilanen V, Salminen K, Seppälä M, Mattila PS, Anttila VJ, Arkkila P. Fecal transplantation, through colonoscopy, is effective therapy for recurrent Clostridium difficile infection. Gastroenterology. 2012 Mar;142(3):490-6. Epub 2011 Dec 7. View Abstract

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Responses

7 Responses to “Faecal Transplantation Works for C. difficile Colitis”

  • Jatin Kanani says:

    Please advice me on any surgeon who you might know who can perform Faecal transplant for UC in the UK

    • Michael Ash says:

      Hello Jatin

      Dr MacConnachie, from Gartnavel General Hospital in Glasgow, has performed just over 20 of the operations since he started in 2003 – there may be others, but I am unaware of them

  • pip haywood says:

    i suffer from ulcerative colitis and just wondered if the precedure would help me,i would certainly welcome the chance to try rather than rely on taking Asacol for the rest of my life

    • Michael Ash says:

      Hello Pip

      Anecdotal evidence combined with the comprehension that loss of bacterial diversity and mucosal tolerance underlies the incidence of IBD suggests that this strategy may well develop in the coming years to be a recognised standard of care. In the meantime if you can find a willing specialist or are prepared to self, treat the risks, subject to your donor being screened for pathogens and preferably being from the same family or geography as well as having a healthy digestive system are very low.

  • ms cailceta says:

    I have ulcerative colitis and diveraticulitis. Could i have the feacal transplant and how much would it cost if i had it privately. I would do anything to get rid of this bowel disease. My daughter days she will be a donor for me as do my family say the same. She is healthy. Please get back to me

    • Michael Ash says:

      Hello
      In both aspects of your gastrointestinal complaints the use of faecal transplant would be experimental. Data for the treatment of inflammatory bowel diseases is increasing but remains sparse – that said the indications are that FT offers legitimate hope for UC patients. Diverticulitis is of course a lifestyle driven illness, that remains something of an enigma, with aggressive management involving antibiotics (which in turn increase the risk for dysbiosis) and surgery – both of which can add complications to any IBD.

      The cost of finding a suitably qualified practitioner or consultant will depend where you are located – there is a well established protocol for conducting home delivered FT using an enema kit – I explain this on this web site – not to imply that this is what you should do, but to give you knowledge that such a treatment carries low risk and is cheap.

      However, the donor should have a full viral and bacterial stool test conducted to be sure they do not inadvertently transfer pathogenic organisms.

  • Merritta says:

    Hi
    I just wondered has anyone actually had a ft in the uk? If so has it worked?

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