Prof. Martin Pall PhD: Explaining Unexplained Illnesses

Prof Pall presented an informed and clinically relevant day of lectures at the Royal Society of Medicine on 12th May 2007
This presentation was recorded using Articulate.

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Prof. Pall Book

Prof. Pall Book

Prof Martin Pall PhD is a scientist on a mission. As someone who has suffered and recovered from chronic fatigue (ME) he feels passionate that science should have an answer to this problem. He has dedicated many years to identifying common pathways and has published his findings in a new book ‘Explaining Unexplained Illnesses’. Prof Pall is not just an academic, he has also supported human trials using his mechanisms and has had the outcomes published in leading journals.

The exciting element for nutritionally orientated clinicians is that his model leans heavily on biochemical abnormalities that do respond to specialised nutritional compounds. We invited Prof Pall to the UK in 2007 to present his work and clinical findings to clinicians and practitioners at the Royal Society of Medicine.

Prof Pall states, that in chronic conditions such as Fibromyalgia, Multiple Chemical Sensitivities, Chronic Fatigue, Post Traumatic Stress Disorders, Alzheimer’s, etc., the initiating stressors of pathogens, heavy metals, viruses etc increase the levels of nitric oxide (NO) in the gut. Unfortunately, high levels of NO can also oxidise the host tissue. Thus in the gut, excess NO can increase inflammation and permeability creating problems for the local and systemic tissues. Too much NO can also deplete the essential antioxidant defences, depressing levels of reduced glutathione (GSH). Low GSH, in turn, increases NO. Nitrite (an intermediate oxidised ion of nitrogen) is known to bind GSH. In essence, a mutually amplifying positive-feedback loop exists between gut inflammation and NO.

A particularly ominous result of excess NO is increased formation of peroxynitrite (ONOO), which then radically affects key biomolecules. ONOO is formed by reaction of NO with superoxide and is much more reactive than parent radicals, reacting with cellular components that alter biochemical and/or genetic potential. What makes it so dangerous is that it reacts with fats (lipids) and proteins (collagen) in the mitochondria, lowering energy metabolism. That means excess NO affects DNA, the cell membrane, and just about everything else! Excessive NO production is associated with arthritis, asthma, diabetes, stroke, septic shock, chronic inflammation, and atherosclerosis. The formation of ONOO plays a principle role in the mechanism of disease described by Prof. Pall, along with NF KappaB and other inflammatory mediators.

These chronically affected patients represent a more complex dilemma for practitioners in how to treat them. Ironically, some normal approaches of removing the ‘stressors’ such as pathogens etc. can potentially cause more cell damage and make their symptoms worse.

Professor Pall’s presentation will help you to:

Professor Martin Pall, PhD, Professor of Biochemistry and Basic Medical Sciences at Washington State University. He is a self recovered chronic fatigue sufferer, who developed and researched the science behind the illness and a route to recovery. His 15 years of specific research into ‘Explaining Unexplained Illnesses’ has resulted in his new book which draws upon more than 1500 scientific references, 15 of his own peer review publications and 5 human trials.

Continuing Professional Development

CPD Approval Credits/hours
British Association for Applied Nutrition and Nutritional Therapy
British Association for Applied Nutrition and Nutritional Therapy
3.5
The Royal College of Physicians has awarded CPD credits for the seminar: 4
GOsC logo BCA logo

General Osteopathic Council/British Chiropractic Association

4
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