Children and Anti-Virals. Are They Worth Combining?
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Comment: A paper out in the British Medical Journal on the 10th August 2009 [1] raises some interesting questions about the benefit of treating children under the age of 12 with neuraminidase inhibitors. This paper looked at 4 RCT’s involving 1766 children of whom 1243 had confirmed seasonal influenza A. Plus three RCT’s for the potential benefits of prophylaxis in 863 children.

The immune system is prone to the same grave misfortunes as any defense system handling weapons: collateral damage that comes with the destruction of the enemy on one’s own territory and friendly fire due to mistaken identity. Whereas the collateral damage is the price we pay for clearance of infections, autoimmunity is a pathological process. Nevertheless, the effector mechanisms involved in both processes are the same. Whether environment can be a cause, a trigger or an amplifier of an autoimmune disease are questions that are being intensively investigated.


