Coeliac Disease – Local & Systemic Consequences

leaky gutCoeliac disease is an inflammatory disorder with autoimmune features that is characterised by destruction of the intestinal epithelium and remodelling of the intestinal mucosa following the ingestion of dietary gluten. The human gut is home to trillions of commensal microorganisms, and we are just beginning to understand how these microorganisms interact with, and influence, the host immune system. This may also include the late onset development of Coeliac Disease, or gluten intolerance.

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Abstracts

DHA & Vit D in Pregnancy, A Key Role for Both

The Safe Foundation for a Healthy Pregnancy

APA logoThe omega-3 DHA is an “essential” fatty acid that the body cannot produce and must be consumed through diet or supplementation. The baby must acquire its DHA from its mother, and she must obtain it by increasing the omega-3s in her daily diet or from daily supplementation.[1] International recommendations suggest that pregnant and nursing women consume 300-600mg of DHA every day to ensure that mothers remain healthy during and after pregnancy, and that their babies have every opportunity for healthy development.[2]

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Reviews

Herbal Adaptogens For Asthma and Adrenal Function

A Blend of Unique Herbs May Have Wide Clinical Application

2008mar_logoIn 2006  a landmark study from the Mt. Sinai School of Medicine in New York, the Weifang Asthma Hospital and the Weifang School of Medicine in China reported on a novel blend of Chinese herbs (named ASHMI) that proved statistically as effective as steroids in alleviating asthma symptoms. Now we report more fully on these unique adaptogenic herbs, which may have far wider application than asthma alone. There were preliminary indications that this formula may in fact restore adrenal function, and thus be useful in relationship to many chronic illnesses associated with adrenal fatigue. Highlights of the new information we include in this article:

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Reviews

Mechanisms of Immune Tolerance to Allergens

Co-evolutionary development of the immune system together with infections and non-infectious environmental proteins (allergens) has generated biologically relevant thresholds and major directions to be taken by the immune system. The default healthy immune response to allergens is expected to be no response, however, detectable T cell and antibody (particularly IgG4 and IgG1) response has been demonstrated in sensitized, but clinically healthy individuals. If an immune response develops in healthy individuals, the immune system shows allergen-specific tolerance by using multiple mechanisms in order to keep the intensity of the inflammation low and tissue destruction small.

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Abstracts

Has Mandatory Folic Acid Supplementation Of Foods Increased The Risk Of Asthma And Allergic Disease?

Folate (the naturally occurring form) and folic acid are forms of a water-soluble B vitamin (B9) that were first synthesized in 1945. Folate functions as an important cofactor in the transfer and use of 1-carbon moieties, primarily methyl groups. An important advance in understanding subclinical folate deficiency came in 1991 with the demonstration that folic acid supplementation before and during pregnancy dramatically reduced the risk of neural-tube defects in newborns. Folate supplementation of women before and during the first trimester of pregnancy has a dose-response effect in preventing neural-tube defects, ranging from a 23% reduction with 200 μg to an 85% reduction with 5000 μg of folic acid per day. The strong evidence demonstrating reduced risks of neural-tube defects led to mandatory folic acid fortification of cereal grain products in the United States by January 1, 1998. Fortification of foods with folic acid in the United States costs about $1,000 per neural-tube defect prevented. Even with all the information on the benefits of folate, many studies show inadequate folate intake among young women. Adequate folate levels have also been associated with reduced risks of coronary artery disease, colorectal cancer, and dementia.

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Abstracts