Immune Tolerance in the GUT Relies on Dendritic Cells

cover_natureThe differing origins of gut dendritic cells — white blood cells that modulate immune responses — may explain how the intestinal immune system manages to destroy harmful pathogens while tolerating beneficial bacteria says an article by Sophie Laffont & Fiona Powrie in Nature journal out on Dec 10th 2009.

The immune system must protect the body from invading pathogens without mounting damaging responses to its own tissues. Dendritic cells, a rare population of white blood cells, have a crucial role in determining the nature of immune reactions and in fine-tuning the balance between tolerance (where the immune system ignores or tolerates an antigen) and the induction of inflammation to destroy pathogenic organisms.

Read the rest of this page »

Microbes in Mum – Act as Inhibitors of Allergy in Children

coverA new twist to the hygiene hypothesis shows that allergic risk can also be modulated by microbial exposure before birth. Mice born to dams that were exposed to bacteria during pregnancy were less likely to develop allergic responses than those born to unexposed mothers. And maternal Toll-like receptor (TLR) signals were required for the transmission of protection.

TLRs are a type of pattern recognition receptor (PRR) and recognise molecules that are broadly shared by pathogens but distinguishable from host molecules, collectively referred to as pathogen-associated molecular patterns (PAMPs).

Read the rest of this page »

Coeliac Disease – Local & Systemic Consequences

leaky gutCoeliac disease is an inflammatory disorder with autoimmune features that is characterised by destruction of the intestinal epithelium and remodelling of the intestinal mucosa following the ingestion of dietary gluten. The human gut is home to trillions of commensal microorganisms, and we are just beginning to understand how these microorganisms interact with, and influence, the host immune system. This may also include the late onset development of Coeliac Disease, or gluten intolerance.

Read the rest of this page »

All Immunity is Mucosal – The GUT is No 1

The Gut is The Formula 1 of Immunity

mi_cimageProperly regulated mucosal immunity is critical to overall health and well being. The cells found in the mucosal surfaces of the body meet on a daily basis, local challenges from foods, microbes and environmental pollutants. The result is a series of immunological decisions that on a single day exceed those made by the systemic immune system in a lifetime.

The immune system bound up in these tissues – mostly the ‘innate immune system’, must translate this infornatic onslaught to the ‘systemic immune system’  affecting the body as a whole. Immune tolerance or homeostasis in these tissues will help ensure adequate nourishment from passing ‘foreign’ food stuffs and so maintain bacterial/commensal balance. It is this bacterial balance that will ensure immunological tolerance so keeping the balance of power in the hands of health promoters (commensals) via this yin and yang relationship.

Read the rest of this page »

Dark Chocolate Vs. Stress – The Dark Side Wins!

UnknownDietary preferences influence basal human metabolism and gut microbiome activity that in turn may have long-term health consequences. The present study reports the metabolic responses of free living subjects to a daily consumption of 40 g of dark chocolate for up to 14 days.

A clinical trial was performed on a population of 30 human subjects, who were classified in low and high anxiety traits using validated psychological questionnaires. Biological fluids (urine and blood plasma) were collected during 3 test days at the beginning, midtime and at the end of a 2 week study. NMR and MS-based metabonomics were employed to study global changes in metabolism due to the chocolate consumption.

Read the rest of this page »

LGG (Culturelle) Resolves Bloating and Distension

XLargeThumb.00004836-200911000-00000.CVFunctional gastrointestinal disorders, a group of functional conditions characterised by the presence of symptoms attributable to the mid or lower gastrointestinal tract, include functional abdominal bloating, which is dominated by a feeling of abdominal fullness or bloating without sufficient criteria for another functional gastrointestinal disorder.

Diagnostic criteria are the presence, for at least 12 weeks, that need not be consecutive, in the preceding 12 months of;

  1. A feeling of abdominal fullness, bloating, or visible distension; and
  2. Insufficient criteria for a diagnosis of functional dyspepsia, IBS, or other functional disorders.[1]

Read the rest of this page »

Confused About Abdominal Bloating? – No More!

adominalMichael Ash BSc(Hons).DO. ND. FDipION reviews the current understanding behind bloating and distension.

The unpleasant symptoms of bloating and abdominal distension are common and bothersome, affecting up to 96% of patients with functional gastrointestinal disorders (such as IBS) and an estimated 30% of the general population. Clear pathophysiologic explanations have been lacking and available treatment options can appear contradictory and ineffective. Treatments will be explored in a follow up review.

Read the rest of this page »

Science Connects Diet And Intestinal Bacteria With Healthier Immune Systems

cover_natureWhilst to nutritionists and most people who understand the role of nutrients in health, the idea that the bacteria in our gut impacts on disease risk seems almost common knowledge, there is still a shortage of hard science to back this up. In the international journal Nature, periodic examples of how science is catching up appear. In the Oct 29th edition an article out of Australia really adds some substance to the role of food and bacteria in health and disease.

Read the rest of this page »

Dissolve Biofilms With Fibrinolytic Enzymes: Autism Support

2009mar_logo

A Novel Approach to Chronic Infection in Autism Spectrum Disorders

An Interview with Peta Cohen, M.S., R.D., founder of Total Life Center in Northern New Jersey. Cohen specializes in treating children with autism using a biomedical / nutritional model. Cohen received her Masters in Clinical Nutrition from New York University and has been a Defeat Autism Now! practitioner for the past ten years.

Read the rest of this page »

Blastocystis hominis. Is It Really A Problem?

Blastocystis hominis cyst-like forms in a wet mount stained in iodine

Blastocystis hominis cyst-like forms in a wet mount stained in iodine

Problem?

Michael Ash BSc DO ND FDipION reviews the latest studies on this pathogen.

Blastocystis is an unusual enteric protozoan parasite of humans and many animals. It has a worldwide distribution and is often the most commonly isolated organism in parasitological surveys. The parasite has been described since the early 1900s, but only in the last decade or so have there been significant advances in the understanding of Blastocystis biology.

Read the rest of this page »

We use cookies and similar tools across our websites to improve their performance and enhance your user experience. Learn more about our Cookies Policy and click I understand, to hide this message.