Omega-3 Fatty Acids – A Promising Novel Therapy For Non-Alcoholic Fatty Liver Disease

coverimageCompared with our ancestors, Western societies today lead a lifestyle that is much more sedentary, probably as a result of cultural changes stemming from modern socio-economic morays. Taking into account differences in body size, our energy expenditure per kilogram of body weight has been estimated to be <40% of that of our prehistoric ancestors.[1] Current estimates suggest that 7 out of 10 adults are inactive or lack adequate conditioning,[2] and this lack of adequate exercise, combined with dietary indiscretion, has contributed to the worldwide epidemic of obesity and non-alcoholic fatty liver disease (NAFLD). NAFLD, is now considered to be around 20–30% prevalence in Western countries.

Read the rest of this page »

Reviews

DHA & Vit D in Pregnancy, A Key Role for Both

The Safe Foundation for a Healthy Pregnancy

APA logoThe omega-3 DHA is an “essential” fatty acid that the body cannot produce and must be consumed through diet or supplementation. The baby must acquire its DHA from its mother, and she must obtain it by increasing the omega-3s in her daily diet or from daily supplementation.[1] International recommendations suggest that pregnant and nursing women consume 300-600mg of DHA every day to ensure that mothers remain healthy during and after pregnancy, and that their babies have every opportunity for healthy development.[2]

Read the rest of this page »

Reviews

Pain Killers Adversely Inhibit Vaccination Benefits

622804The questions concerning the benefits Vs risks of vaccination in light of the recent global approach to H1N1 (novel influenza) vaccine recommendations has thrown this area of medicine under a very bright spotlight. Leaving aside the question ‘to vaccinate or not’ a recent article has raised a simple and useful question. If I take a non steroidal pain killer (NSAID’s) to reduce post vaccine discomfort, or are ingesting them for other reasons does it affect my vaccine promoted immune response?

Read the rest of this page »

News

Whats New in The Understanding Of The Immunology Of Ulcerative Colitis?

medscape-todayIBD’s are characterised by wasting and chronic intestinal inflammation induced by many different cytokine-mediated pathways. It is clearly recognised that medical and surgical interventions do not cure Crohn’s disease because relapse is the rule after remission.

Until a few years ago, IBD was classified into Th1-dependent, that is, Crohn’s disease, and Th2-dependent, that is, ulcerative colitis, phenotypes. However, in recent years, it has been shown that new T-cell subclasses, that is, Th17 and regulatory T cells (TR), exist independently of Th1 and Th2 and that they play a central role in modulating IBD.

Read the rest of this page »

Abstracts

French Study Contradicts FSA’s Opinion on Organic Food Benefits

agro_coverA  report just published by the French Agency for Food Safety (AFSSA), the equivalent to the UK’s Food Standards Agency has described organic foods as being better for you,contain less pesticides and nitrates, both of which have been linked to a range of health problems including diabetes and Alzheimer’s.

This up-to-date exhaustive and critical evaluation of the nutritional quality of organic food  has found organic foods have higher levels of minerals and antioxidants, counter opposing the recent FSA report that questioned the benefits of growing and consuming organic foods.

Published in the peer reviewed journal Agronomy for Sustainable Development  this review carries substantive scientific opinion. It defines a number of advantages provided by the organic food production methods.

Read the rest of this page »

Abstracts

Phosphatidylcholine (PC) Controls Inflammation in Ulcerative Colitis

BMC Gastroenterology Logo

Phosphatidylcholine (PC) is a major lipid of the gastrointestinal mucus  layer. We  recently showed  that mucus from patients suffering  from ulcerative colitis  has low levels of PC. Clinical studies reveal that the therapeutic addition of PC to the  colonic mucus using slow release preparations is beneficial.

Read the rest of this page »

Abstracts

Walnuts Lower Cholesterol and Other CV Risk Factors

Background: Consumption of nuts has been associated with a decreased risk of cardiovascular disease events and death. Walnuts in particular have a unique profile: they are rich in polyunsaturated fatty acids, which may improve blood lipids and other cardiovascular disease risk factors.

Read the rest of this page »

Abstracts

Dietary Reference Intakes for EFA’s

There is considerable interest in the impact of (n-3) long-chain PUFA in mitigating the morbidity and mortality caused by chronic diseases. In 2002, the Institute of Medicine concluded that insufficient data were available to define Dietary Reference Intakes (DRI) for eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA), noting only that EPA and DHA could contribute up to 10% toward meeting the Adequate Intake for alpha-linolenic acid. Since then, substantial new evidence has emerged supporting the need to reassess this recommendation.

Read the rest of this page »

Abstracts

Omega-6 Fatty Acids and Risk for Cardiovascular Disease

A large body of literature suggests that higher intakes of omega-6 (or n-6) polyunsaturated fatty acids (PUFAs) reduce risk for coronary heart disease (CHD). However, for the reasons outlined below, some individuals and groups have recommended substantial reductions in omega-6 PUFA intake. The purpose of this advisory is to review evidence on the relationship between omega-6 PUFAs and the risk of CHD and cardiovascular disease.

Read the rest of this page »

Abstracts

Is docosahexaenoic acid, an n–3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioural tests in humans and animals

This review is part of a series intended for non specialists that will summarise evidence relevant to the question of whether causal relations exist between micronutrient deficiencies and brain function. Here, we focus on experiments that used cognitive or behavioural tests as outcome measures in experimental designs that were known to or were likely to result in altered brain concentrations of the n–3 fatty acid docosahexaenoic acid (DHA) during the perinatal period of “brain growth spurt.”

Read the rest of this page »

Reviews