The Gut Microbiota and ME/CFS

A paper out in the journal Anaerobe explores the potential role of our commensal bacteria and the development and progression of chronic fatigue syndrome, also known as myalgic encephalomyelitis.[1]

Developing a theme started in part by the Australian scientist Thomas Borody and colleagues[2] in which they utilised the method of faecal transplant therapy and identified that 70% of the patients responded initially and after a prolonged follow up period ((15-20 years) found that 58% had a sustained response, suggesting that the relationship between bacteria in the digestive tract and symptoms of CFIDS may have a credible mechanism for intervention.

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Intractable Fatigue in Chronic Lyme Disease: Lipid Replacement Therapy (LRT®) Effective Against Fatigue

A 2012 study in the international Journal of Functional Foods in Health and Disease finds that glycophospholipids significantly reduce intractable fatigue in long-term patients who are positive on the western blot test for Borrelia burgdorferi infection, known as Lyme Disease.1 The western blot is the gold standard test for this infection, which is the most common vector-borne illness in North America.

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Membranes in Motion: The Fluid Mosaic Membrane Model

It isn’t every newsletter issue that FOCUS has the privilege of featuring a scientist whose theory of a fundamental biological phenomenon is accepted throughout the biological and medical sciences as the standard textbook model. Such is the case with S. J. Singer’s and Garth Nicolson’s landmark theory of the Fluid Mosaic Model of cell membranes. This model, proposed in 1972 and published in the prestigious journal SCIENCE, has been called a “unified theory” of the cell membrane. This model has been tested and retested for many decades, and it is now believed to accurately predict the structure and behaviour of all cellular membranes. Over the intervening years this theory has been confirmed by many sophisticated physical and chemical techniques, including one known as freeze-fracture electron microscopy.

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A Special Note from Garth Nicolson PhD Why Lipid Replacement Therapy(LRT®) is Key to our Health

In the mid-1960s I had the honour of working with Professor S. J. Singer on the Fluid Mosaic Model of Biological Membranes for my doctoral thesis. At the time the cell membrane was thought to be a rather static three-layer structure with lipids sandwiched in between protein inner and outer layers. However, we knew that this static 3-layer structure did not fit with the wide range of physical and chemical information that had recently become available on membrane structure.

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Mitochondria and the Anti-Aging Role Of Lipid Replacement Therapies

Introduction

There is a simple arithmetic to human life that holds deep insights into health and disease—the rate of our cell generation minus the rate of our cell loss determines the growth or degeneration of a tissue.

Recent evidence indicates that the interplay between our mitochondria, mitophagy (the removal of impaired mitochondria by a specialised version of the autophagy pathway by delivering mitochondria to the lysosomes for degradation) and autophagy links aging to health or disease.[1]

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Fatigue, Immunity and Inflammation:– Their Resolution Using Natural Medicine.

Michael E. Ash BSc DO ND, Robert Settenari M.S and Prof. Garth L. Nicolson Ph.D explain the relationship between energy deficit, mitochondrial membrane quality, the immune system, inflammation and how to recover from persistent fatigue using validated natural medicine.

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Bad Decisions – Due to Fatigue/Loss of Willpower?

No matter how we approach decisions and how careful we are, some bad ones are made, and others are unnecessarily delayed – organisation, procrastination and fear dominate the thoughts of many paralysed by the thought of completing the decision making task.

To complicate this further, there is the little understood effect of ‘decision fatigue’, the act of making so many decisions in a day that eventually even the best trained start to do things that in the cold light of day are difficult to justify.[1]

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Dr James Wilson – Recovering from Adverse Stress & Fatigue

Dr James WilsonOn the weekend of October 16th & 17th this year, Dr James Wilson is travelling from Arizona to present a seminar and workshop combination at The Royal Society of Medicine, London on “Recovering from Adverse Stress & Fatigue”.

The Autumn Seminar aims to provide a vital update of information beyond Dr. Wilson’s book ‘Adrenal Fatigue – The 21st Century Stress Syndrome’.

More about Dr Wilson’s Seminar

CFIDS Virus XMRV- Link Challenged

Controversial link. A previous study of chronic fatigue syndrome pointed to a retrovirus found in cancerous prostate cells

Last October 2009 the journal Science published a paper suggesting that a virus could be linked to CFIDS as well as prostate cancer. This was commented on in this site. Initial enthusiasm for this potential pathogen explanation for the chronic and debilitating condition has taken a couple of knocks as two papers have questioned the link. Scientists in the initial study found DNA traces of a virus in the blood cells of two-thirds of 101 patients with CFIDS, compared with 4% of 218 healthy controls. XMRV is a rodent retrovirus also implicated in an aggressive prostate cancer, though why it might cause or be associated with CFIDS remains unclear.

This naturally seemed to provide a plausible association with an infectious agent that would mesh with the common development of the condition following a viral infection.

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