Perilla Targets Inflammation: Joins Traditional Gut Nutrients as Potent Anti-spasmodic and Anti-inflammatory

The remedies for gastrointestinal complaints are legion and stretch back far in human history. Ancient Chinese physicians prescribed anise for flatulence, while Dioscorides, chief physician for the Roman army, recommended garlic for parasites. Many are effective and stand the test of time, but contemporary scientific research on novel extracts offers up surprising new finds. The Asian plant, Perilla (Perilla frutescens) for example, offers valuable assistance in the management of functional gut problems.

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Perilla Extract (Benegut®) Improves IBS symptoms

A study published in the BMC Complementary and Alternative Medicine Journal identifies a number of benefits and improved function, achieved in people with IBS ( a functional loss of tolerance in the GI Tract) when consuming a 300mg daily dose of Perilla Extract.[1]

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Anal gas evacuation and colonic microbiota in patients with flatulence: effect of diet

Conclusions Patients complaining of flatulence have a poor tolerance of intestinal gas, which is associated with instability of the microbial ecosystem.[1]

Significance of this study

What is already known on this subject?

Faecal Microbiota Transplantation for Inflammatory Bowel Disease

The use of faecal transplantation as a therapeutic tool for not only Clostridium Difficile Infection but as a mechanism for changing the composition of colonic microbiota for the purpose of resolving numerous persistent inflammatory conditions is starting to gain increased interest in the research and medical communities.

Medscape recently published a summary of many of the key areas and I have extracted and edited a small section for peoples review.

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Faecal Transplant (FT) and IBD

I have explored the role of appropriate transplantation in the resolution of MRSA infection that fails to resolve with antibiotic therapy, and have intimated that other conditions of the bowel and linked tissues may also benefit. The model is: that loss of mucosal tolerance underlies the pathology of inflammatory bowel disease and is also linked to irritable bowel syndrome. These altered states of function reflect a combination of environmental, genetic and emotional events that coalesce into a wide range of conditions.

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The Relevance of Prior Parasitic Infection and The Risk of IBS And CFS

Giardia lamblia (synonymous with Giardia intestinalis, Lamblia intestinalis and Giardia duodenalis) is a flagellated protozoan parasite that colonises and reproduces in the small intestine, causing giardiasis. The giardia parasite attaches to the epithelium by a ventral adhesive disc, and reproduces via binary fission. Giardiasis does not spread via the bloodstream, nor does it spread to other parts of the gastro-intestinal tract, but remains confined to the lumen of the small intestine.

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IBS And Food – Is There A Link?

There is a growing body of evidence to suggest that certain dietary constituents exacerbate symptoms and perhaps contribute to the pathogenesis of IBS. Patients have long associated their IBS symptoms with the ingestion of certain foods, combinations of foods, or generally with meals. Response rates from elimination diets have ranged from 15%-71%,[1] with wheat, milk, and eggs being the most commonly implicated foods.

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IBS Succesfully Managed by Nutritional Therapy

It will be of no real surprise to know that the incidence of irritable bowel syndrome (IBS) is common. Around the world it is estimated that some 10-20% of the population suffer from it. This is not an inconsequential number, and apart from the miserable statistics, it comes with loss of function, misery, anxiety, pain, bloating, altered bowel habits and loss of quality of life.

Whilst a clear explanation of the cause remains somewhat elusive, there is an increasing acceptance that the relationship between the brain-gut axis, central nervous system, peripheral stress response, infection, dysbiosis, barrier defects, inflammation and immune imbalance play significant roles in the causation.

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Review of Role of Probiotics & IBS Resolution

Functional gut problems, such as those classified by the Rome criteria as IBS are a significant health problem for many people. The use of probiotics as a single or multiple intervention offers a potential route to resolution, but the data is as yet inconsistent and in need of further clarification. This is the opinion of a group from Thames Valley University in a recently published review.[1]

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Dientamoeba Fragilis is it Really a Problem

Dientamoeba Fragilis

First, some background to this parasite and a brief discussion of what may be used pharmaceutically and then a review of how a non-drug approach may be applied through the understanding of the mechanisms employed by the organism and its relative susceptibility to eradication strategies.

Dientamoeba fragilis (D. fragilis)is a trichomonad (a genus of anaerobic protists that are parasites of vertebrates) parasite found in the gastrointestinal tract of humans and implicated as a cause of gastrointestinal disease. D. fragilis has been found in most parts of the world in both rural and cosmopolitan areas. Infection with D. fragilis is called Dientamoebiasis and is associated variously with symptoms of abdominal pain, diarrhoea, weight loss, and fever.[1]

Dientamoeba fragilis is a parasite that causes gastrointestinal problems. Despite its name, Dientamoeba fragilis is not an amoeba but a flagellate. This protozoan parasite produces trophozoites; cysts have not been identified. Infection may be either symptomatic or asymptomatic.

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