Building Bone: The Novel Role of Tocotrienols

An Interview With Professor Dr. Ima-Nirwana Soelaiman, MBBS, PhD, Deputy Dean (Research and Innovation) Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

Biography: The focus of Dr. Ima-Nirwana’s research is the impact of natural products on bone metabolism and osteoporosis, with special emphasis on tocotrienols. Dr. Ima-Nirwana has published 122 articles in scientific journals. Together with her team she has presented her work at over a hundred local and international conferences.  The results from her animal studies have consistently shown that tocotrienols can prevent and reverse osteoporosis due to stressors, including menopause, estrogen and androgen deficiency, steroid excess, nicotine exposure and oxidative stress and inflammation. She is currently planning clinical trials on tocotrienols and osteoporosis in the USA and in Malaysia. She is a member of the Malaysian Osteoporosis Society and the Malaysia Endocrine and Metabolic Society. She holds a patent within Malaysia for the use of tocotrienol for bone health in humans.

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Oestrogen Metabolism is Beneficially Manged By Plant Extract (DIM)

00bookDiindolylmethane (DIM)
A phytonutrient and plant indole found in cruciferous vegetables including broccoli, brussels sprouts, cabbage, cauliflower and kale, with potential antiandrogenic and antineoplastic activities. As a dimer of indole-3-carbinol, diindolylmethane (DIM) promotes beneficial oestrogen metabolism in both sexes by reducing the levels of 16-hydroxy oestrogen metabolites and increasing the formation of 2-hydroxy oestrogen metabolites, resulting in increased antioxidant activity. Although this agent induces apoptosis in tumor cells in vitro, the exact mechanism by which DIM exhibits its antineoplastic activity in vivo is unknown. Check for active clinical trials using this agent. (NCI Thesaurus)

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Vit D Optimisation Requires Supplementation Says Harvard

logo-HHP_mastheadThe conservative Harvard Medical School in the USA normally promotes micronutrient intake being derived from food stuffs alone. The Health Publications Bulletin out in Sept 2009 says that from the perspective of Vitamin D food sources may be inadequate and that supplementary intake is required to meet physiological optimisation. (See Video)

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Impaired Gastric Acidification Negatively Affects Calcium Homeostasis and Bone Mass

Calcium deficiency in the elderly is associated with low gastric acid secretion and bone loss. A new study linking defects in gastric acid secretion with bone destruction and impaired mineralization bolsters the view that calcium supplements can prevent these bone defects-but do they all work. This paper suggests that altered acidification of the stomach and specific gene deficiencies will dictate the form of calcium supplementation most suitable for the reduction and resolution of osteoporosis.

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Inhibition of Osteoblastic Bone Formation by Nuclear Factor-kappaB

An imbalance in bone formation relative to bone resorption results in the net bone loss that occurs in osteoporosis and inflammatory bone diseases. Although it is well known how bone resorption is stimulated, the molecular mechanisms that mediate impaired bone formation are poorly understood.

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Oregano Helps Stop Inflammation and Bone Degeneration

Comment: Chronic inflammation is known to be associated with increased episodes of heart attacks and with such autoimmune disorders as diabetes, lupus, rheumatoid arthritis and multiple sclerosis among others. One way to fight such inflammation is through nutrition – and specifically, as researchers from the University of Bonn and the ETH Zurich have discovered, by including oregano in our diets.

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